
GLP-1 Medications: How Semaglutide and Tirzepatide Work
What these medications do to appetite and metabolism, who they're a fit for, and what results to expect month by month.
The Journal
Clear, physician-reviewed writing on weight loss, longevity, hormones, and sexual health—so you can make informed decisions about your care.
Featured

What these medications do to appetite and metabolism, who they're a fit for, and what results to expect month by month.
Weight Loss

Why some patients do better on smaller, slower-titrated doses—and how providers decide when a gentler ramp makes sense.

Appetite drops fast on GLP-1s, so what you eat matters more. A simple framework for hitting protein and fiber on less food.

The scale stalls for almost everyone eventually. Here's what's actually going on and the levers your provider can pull.
Longevity

A grounded look at what's evidence-based in longevity medicine—and what's hype—across the protocols we prescribe.

NAD+ is everywhere in longevity marketing. We separate the mechanisms with real data behind them from the wishful thinking.

How growth-hormone-releasing peptides differ from HGH itself, what they help with, and the monitoring that keeps them safe.
Hormones

Lab reference ranges are wide. Here's how physicians interpret total T, free T, and the markers that actually shape your protocol.

Hormone care isn't just a men's-health topic. What women should know about testosterone, estrogen, and energy at every stage.

Low energy rarely traces back to a single number. The connected panel your provider reads before adjusting anything.
Sexual Health

Sildenafil vs. tadalafil, daily vs. as-needed dosing, and when ED is a signal worth investigating further.

Onset, duration, and daily vs. as-needed dosing. A clear comparison to help you and your provider pick the better option.
Fitness

Medication is one lever. Here's how to build the training and nutrition around it to keep muscle while you lose fat.

Lifting during a cut isn't optional—it's how you keep the muscle that keeps your metabolism up. A practical training template.

Progress is built during recovery, not just training. Where sleep, deload weeks, and recovery peptides actually fit in.